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Review Article
Hearing loss molecular analysis
1 ENT Department, Federal Teaching Hospital, Ido-Ekiti/Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
2 Community Medicine Department, Federal Teaching Hospital Ido-Ekit/Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
3 Department of Surgery, Federal Medical Centre, Birnin Kebbi, Kebbi State, Nigeria
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Shuaib Kayode Aremu
ENT Department, Federal Teaching Hospital, Ido-Ekiti/Afe Babalola University, Ado-Ekiti,
Nigeria 371002
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Article ID: 100010O04SA2018
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How to cite this article
Aremu SK, Rasaq AK, Wasiu O. Hearing loss molecular analysis. Edorium J Otolaryngol 2018;4:100010O04SA2018.ABSTRACT
In the past it was difficult to identify children with hearing loss, and many newborns remained undiagnosed, but since early 2000, when Universal Newborn Hearing Screening (UNHS) came into place and made successful strides in hearing loss research and have been able to provide screening of hearing loss at an early age of one month, hence they have been able to receive comprehensive treatment. UNHS also tracks infants for further follow up and wherever necessary. The two main methods used in newborn screening are otoacoustic emission and automated auditory brain stem response. Medical evaluation should begin as soon as possible when hearing loss is suspected, so as to complete prenatal, medical, and family history. Demands have been made to use DNA testing in detecting the molecular basis of hereditary hearing loss. The identification of genes and gene defects faces a lot of challenges due to the fact, there is tremendous genetic heterogeneity, but despite that, there has been successful genetic studies of hearing loss in isolated populations and consanguineous families. Hearing loss is common in patients with mitochondrial disorders, affecting over half of all cases at some time in the course of the disease. Hearing loss has seen some research undertaken to the point now that deafness can be treated and this is through cochlea implantation.
Keywords: Genetic test, Hearing loss, Molecular analysis, Sensorineural
SUPPORTING INFORMATION
Author Contributions
Shuaib Kayode Aremu - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Adewoye Kayode Rasaq - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Omotosho Wasiu - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2018 Shuaib Kayode Aremu et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
