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Surgical stress response following otolaryngology head and neck surgery as assessed by serum interleukin-6 level
Kenichi Takano1, Naoki Hyakushima2, Ryuta Kamekura3, Fumie Ito4, Tetsuo Himi5
1MD, PhD, Associate Professor, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
2MD, PhD, Chief Physician, Department of Otolaryngology, KKR Sapporo Medical Center Tonan Hospital, Sapporo, Japan
3MD, PhD, Medical staff, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
4MD, Medical staff, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
5MD, PhD, Professor and Chairman, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan

Article ID: 100009O04KT2017
doi:10.5348/O04-2017-9-OA-2

Address correspondence to:
Kenichi Takano
Department of Otolaryngology Sapporo Medical University School of Medicine
S1W16, Chuo-ku
Japan

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How to cite this article
Takano K, Hyakushima N, Kamekura R, Ito F, Himi T. Surgical stress response following otolaryngology head and neck surgery as assessed by serum interleukin-6 level. Edorium J Otolaryngol 2017;3:7–12.


Abstract

Aims: Various head and neck surgical procedures are performed in otolaryngology, which are associated with wide range of surgical stress. Currently, minimally invasive surgeries are preferred and widely accepted. The purpose of this study was to assess the postoperative stress response in order to determine surgical stress in head and neck otolaryngology. Methods: Serum interleukin-6 (IL-6) level of 59 patients who underwent otolaryngology surgery under general anesthesia was measured by enzyme-linked immunosorbent assay 24 h post-surgery. Patients were categorized into nine groups according to the surgery
Methods: (a) Ear, (b) Nose, (c) Larynx, (d) Tonsil, (e) Adenoid and tonsil, (f) Parotid gland, (g) Thyroid, (h) Head and neck tumors (HNT)-1, and (i) HNT-2. We analyzed the correlation between serum IL-6 level and the duration of surgery, blood loss, and C-reactive protein (CRP) level. Further, we investigated the postoperative serum IL-6 level of patients in each group.
Results: There was a significant correlation between serum IL-6 level and the duration of surgery, blood loss, and CRP level. Serum IL-6 level was significantly higher in the HNT than any other groups.
Conclusion: Serum IL-6 measurement is valuable to indicate degree of surgical stress associated with various otolaryngology head and neck surgical procedures.

Keywords: Interleukin-6, Head and neck surgery, Postoperative stress response, Surgical stress


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Author Contributions
Kenichi Takano – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Naoki Hyakushima – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ryuta Kamekura – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Fumie Ito – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tetsuo Himi – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Kenichi Takano et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About the Authors

Kenichi Takano is Associate Professor at Department of Otolaryngology, Sapporo Medical University, School of Medicine. His area of interest include microscopic and endoscopic ear surgery. He has published more than 80 research papers.



Naoki Hyakushima is the Chief Physician at the Department of Otolaryngology, Sapporo Tonan Hospital. His area of interest include head and neck surgery.



Ryuta Kamekurais the Assistant Professor at Department of Otolaryngology, Sapporo Medical University, School of Medicine. His area of interest include allergic and immune disorders.



Fumie Ito is a graduate student at Department of Otolaryngology, Sapporo Medical University, School of Medicine. Her area of interest include allergic disorders.



Tetsuo Himi is the Chairman and Professor of the Department of Otolaryngology, Sapporo Medical University, School of Medicine. His area of interest include otologic surgery and vestibular disorders.